Degrade. Stabilize. Relocalize.

Programmable protein modulation.

We have a rich toolkit for editing the genome and transcriptome, but an equivalent framework for the proteome has remained elusive. UbiquiTx has built an AI-native platform for programmable modulation of the proteome — turning any protein target into one we can precisely modulate, not just knock out.

The platform

CLIPs: Chimeric Ligands for Induced Proximity.

A single, modular construct: an AI-designed guide peptide, joined by a flexible linker to a swappable effector enzyme.

01

Any surface

No binding pocket required. Guide peptides engage flat, non-conformational surfaces that PROTACs and molecular glues can't reach.

02

Full modulation range

Swap the effector to degrade, stabilize, or relocalize the same target — not degradation alone.

03

Always functional

Binding and function happen in the same step, so every hit from a screen is a functional one — nothing to validate twice.

Platform engine

Two flywheels generate every functional hit.

Multiplexed peptide screening finds the best binders first. Combinatorial CLIP assembly then turns those winners into a functional cellular outcome — degraded, stabilized, or relocalized.

BINDER DISCOVERY binding & selectivity DESIGN SCREEN MEASURE LEARN
① Peptide binder discovery
multiplexed
Winner binders
CLIP ASSEMBLY functional phenotype ASSEMBLE SCREEN MEASURE REFINE
② Combinatorial CLIP assembly
Functional hit ✓
01

10,000+ sequences per campaign

Multiple protein language models generate and rank candidates — not hand-engineered guesses.

02

Binding and functional results are the moat

Every cycle produces both binding and functional readouts — proprietary data no public database has.

03

Each cycle faster and more precise

Design–screen–measure–learn compounds — every round sharpens the next, across every program.

Target Hypothesis Confirmation Services

De-risk targets before chemistry commits.

Delivers in-cell, mechanism-matched modulation of a nominated target, with dose-response, kinetics, and PTM/isoform selectivity — before partners commit capital.

Protein editing · UbiquiTx

CLIPs

Delivers a mechanism-matched go/no-go on a nominated target by addressing a protein directly.

DNA editing

CRISPR

Sequence-level and permanent. Powerful for somatic targets, but acts on the gene.

RNA editing

siRNA / ASO

Knockdown only. Transient, with limited tissue reach.

Therapeutic Pipeline

The same engine builds wholly-owned medicines.

A pipeline in oncology and regenerative disease, advancing on non-dilutive funding alongside the validation business rather than competing with it for capital.

Hepatocellular carcinoma

Mutation-driven oncology
Degradation

HPV-associated cancers

Head & neck, cervical, anal
Degradation

Severe alcoholic hepatitis / MASH

Liver disease
Stabilization
Team

A leading management team, backed by proven scientific founders.

Executive team
Mathew Barnett, MBA

Mathew Barnett, MBA

CEO
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Mark Shearman, PhD

Mark Shearman, PhD

CSO
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Peter Fekkes, PhD

Peter Fekkes, PhD

Head of Drug Discovery
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Scientific co-founders
Joseph Jacobson, PhD

Joseph Jacobson, PhD

MIT · Media Lab, Molecular Machines Group
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Matthew DeLisa, PhD

Matthew DeLisa, PhD

Cornell · Chemical & Biomolecular Engineering
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Pranam Chatterjee, PhD

Pranam Chatterjee, PhD

UPenn · Biomedical Engineering & Computer Science
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Built on a decade of peer-reviewed science from our founders.

Read our publications →
Get in touch

The protein layer, finally programmable.

For partnership, licensing, and investment inquiries, we'd be glad to talk.